Abstract
Postoperative atrial fibrillation (POAF) is linked with increased morbidity, mortality rate and financial liability. About 20–50% of patients experience POAF after coronary artery bypass graft (CABG) surgery. Numerous review articles and meta-analyses have investigated links between patient clinical risk factors, demographic conditions, and pre-, peri- and post-operative biomarkers to forecast POAF incidence in CABG patients. This narrative review, for the first time, summarize the role of micro-RNAs, circular-RNAs and other gene expressions that have shown experimental evidence to accurately predict the POAF incidence in cardiac surgery patients after CABG. We envisage that identifying specific genomic markers for predicting POAF might be a significant step for the prevention and effective management of this type of post-operative complication and may provide critical perspective into arrhythmogenic substrate responsible for POAF.
Highlights
Postoperative atrial fibrillation (POAF) occurs in 20–50% of coronary artery bypass graft (CABG) patients during postoperative stay [1]
We report the available experimental evidence of several miRNAs such as miRNA-483–5p [34], miRNA-29a [35], miRNA-23a [36], miRNA-26a [36], miRNA-199a [16], miRNA-1 [37], and miRNA-133a [37], one circRNA: circRNA-025016 [38], and selected gene expressions such as mitochondrial DNA [39,40], and other single nucleotide polymorphisms (SNPs) such as vesicular overexpressed in cancer–prosurvival protein 1 gene (VOPP1) [41], rs3740563 [42], rs10504554 [43], rs2249825 [44], rs4572292 [45], rs11198893 [45], rs10033464 [46,47], rs2200733 [46,47,48] and rs13143308 [48] used previously as potential elements predicting POAF risk following CABG surgery
We intended to assess relevant studies by examining the quality of the previously reported role of miRNA, circRNA and SNPs collected from either tissue, blood or plasma preoperatively and perioperatively among patients undergoing CABG surgery with and without cardiopulmonary bypass (CPB)
Summary
Postoperative atrial fibrillation (POAF) occurs in 20–50% of coronary artery bypass graft (CABG) patients during postoperative stay [1]. The relationship between the function of miRNAs, circRNAs, and gene expressions with POAF risk development in CABG patients has not been thoroughly reviewed in published literature. In this narrative review, we report the available experimental evidence of several miRNAs such as miRNA-483–5p [34], miRNA-29a [35], miRNA-23a [36], miRNA-26a [36], miRNA-199a [16], miRNA-1 [37], and miRNA-133a [37], one circRNA: circRNA-025016 [38], and selected gene expressions such as mitochondrial DNA (mtDNA) [39,40], and other single nucleotide polymorphisms (SNPs) such as vesicular overexpressed in cancer–prosurvival protein 1 gene (VOPP1) [41], rs3740563 [42], rs10504554 [43], rs2249825 [44], rs4572292 [45], rs11198893 [45], rs10033464 [46,47], rs2200733 [46,47,48] and rs13143308 [48] used previously as potential elements predicting POAF risk following CABG surgery
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