Abstract
Unfortunately, page 746 of this manuscript, published in the April 26, 2005 issue of Current Biology, contained an error. In the sentence “Using the same procedure, we readily detected Drosha cleavage products corresponding to 3′ extremity of the mir434, mir435, and mir431 stem loops,” mir435 should have been mir433. The authors regret the error. RNAi-Mediated Allelic trans-Interaction at the Imprinted Rtl1/Peg11 LocusDavis et al.Current BiologyApril 26, 2005In BriefThe Dlk1-Gtl2 imprinted domain, encompassing the callipyge (CLPG) locus in sheep, has recently been shown to harbor a large number of maternally expressed miRNA genes [1, 2]. Two of these (mir127 and mir136) are processed from a transcript (antiPeg11) that is antisense to Rtl1/Peg11, a paternally expressed intronless gene with homology to the gag and pol polyproteins of Sushi-like retroelements [3]. We herein demonstrate that several additional miRNAs are processed from antiPeg11 and that these regulate Rtl1/Peg11 in trans by guiding RISC-mediated cleavage of its mRNA. Full-Text PDF Open Archive
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