Abstract
RNA-binding proteins control the metabolism of RNAs at all stages of their lifetime. They are critically required for the post-transcriptional regulation of gene expression in a wide variety of physiological and pathological processes. Rbm24 is a highly conserved RNA-binding protein that displays strongly regionalized expression patterns and exhibits dynamic changes in subcellular localization during early development. There is increasing evidence that it acts as a multifunctional regulator to switch cell fate determination and to maintain tissue homeostasis. Dysfunction of Rbm24 disrupts cell differentiation in nearly every tissue where it is expressed, such as skeletal and cardiac muscles, and different head sensory organs, but the molecular events that are affected may vary in a tissue-specific, or even a stage-specific manner. Recent works using different animal models have uncovered multiple post-transcriptional regulatory mechanisms by which Rbm24 functions in key developmental processes. In particular, it represents a major splicing factor in muscle cell development, and plays an essential role in cytoplasmic polyadenylation during lens fiber cell terminal differentiation. Here we review the advances in understanding the implication of Rbm24 during development and disease, by focusing on its regulatory roles in physiological and pathological conditions.
Highlights
RNA-binding proteins (RBPs) play key roles in the post-transcriptional regulation of gene expression in a variety of biological processes
Loss of Rbm24a reduces the poly(A) tail length of many crystallin the post-transcriptional regulation of several genes involved in the specification of the lens placode, mRNAs, which severely prevents the accumulation of lens transparent proteins and causes cataract such as Pax6 and Sox2
Loss of Rbm24a reduces the poly(A) tail early development [83]. This correlative evidence further supports a potential interaction between length of many crystallin mRNAs, which severely prevents the accumulation of lens transparent these RBPs in regulating CPA during lens differentiation
Summary
RNA-binding proteins (RBPs) play key roles in the post-transcriptional regulation of gene expression in a variety of biological processes. Vertebrate cells express hundreds to thousands of RBPs that display unique binding activity to their RNA targets and specific interaction with other protein partners. They control RNA metabolism at multiple levels, from alternative splicing, to transport, subcellular localization, stability, polyadenylation, and translation [1]. A number of important questions such asunanswered its dynamicand subcellular localization and tissue-specific function,subcellular the modulation of its remain await further investigation, such as its dynamic localization activity through interaction other partners, and its potential implication in with human pathologies. Understanding the regulatory roles of Rbm in development and disease
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