Abstract
RNA-binding motif protein 39 (RBM39), as a key factor in tumor-targeted mRNA and protein expression, not only plays a vital role in tumorigenesis, but also has broad development prospects in clinical treatment and drug research. Moreover, since RBM39 was identified as a target of sulfonamides, it has played a key role in the emerging field of molecule drug development. Hence, it is of great significance to study the interaction between RBM39 and tumors and the clinical application of drug-targeted therapy. In this paper, we describe the possible multi-level regulation of RBM39, including gene transcription, protein translation, and alternative splicing. Importantly, the molecular function of RBM39 as an important splicing factor in most common tumors is systematically outlined. Furthermore, we briefly introduce RBM39’s tumor-targeted drug research and its clinical application, hoping to give reference significance for the molecular mechanism of RBM39 in tumors, and provide reliable ideas for in-depth research for future therapeutic strategies.
Highlights
Cancer has always been regarded as a highly complex disease, which seriously threatens human health and life
● RNA-binding motif protein 39 (RBM39) is indirectly involved in tumor growth and progression by regulating transcription of many tumor-related genes, protein translation, and alternative splicing
● RBM39 is identified as a target of sulfonamides, and it has played a key role in the emerging field of small molecule drug development
Summary
Caipeng Xu1,2,3,4, Xiaohua Chen, Xuetian Zhang, Dapeng Zhao, Zhihui Dou, Xiaodong Xie, Hongyan Li1,2,3,4, Hongying Yang, Qiang Li1,2,3,4,7,8 ✉, Hong Zhang1,2,3,4,7,8 ✉ and Cuixia Di1,2,3,4,7,8 ✉. RNA-binding motif protein 39 (RBM39), as a key factor in tumor-targeted mRNA and protein expression, plays a vital role in tumorigenesis, and has broad development prospects in clinical treatment and drug research. Since RBM39 was identified as a target of sulfonamides, it has played a key role in the emerging field of molecule drug development. We describe the possible multi-level regulation of RBM39, including gene transcription, protein translation, and alternative splicing. ● RBM39 is indirectly involved in tumor growth and progression by regulating transcription of many tumor-related genes, protein translation, and alternative splicing. ● RBM39 is identified as a target of sulfonamides, and it has played a key role in the emerging field of small molecule drug development
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