Abstract

The Key Features of RNA Silencing.- Selected Strategies for the Delivery of siRNA In Vitro and In Vivo.- RNAi Suppression and Its Application.- Strategies to Prevent siRNA-Triggered Cellular Toxicity.- RNAi in Malignant Brain Tumors: Relevance to Molecular and Translational Research.- Silencing Huntington's Disease Gene with RNAi.- Application of Dicer-Substrate siRNA in Pain Research.- RNAi Treatment of HIV-1 Infection.- Application of RNA Interference to Treat Conditions Associated with Dysregulation of Transient Receptor Potential Vanilloid 1 Channel.- Harnessing RNAi-Based Functional Genomics to Unravel the Molecular Complexity Underlying Skin Pigment Variation.- mRNA Structure and its Effects on Posttranscriptional Gene Silencing.- Antisense RNA-Mediated Regulation of the p53 Tumor Suppressor.- Antisense Oligonucleotides: Insights from Preclinical Studies and Clinical Trials.- What can the New Hammerhead Ribozyme Structures Teach us About Design?.- microRNA Biogenesis and its Impact on RNA Interference.- MicroRNAs in Epithelial Antimicrobial Immunity.- Emerging Roles of Long Noncoding RNAs in Gene Expression and Intracellular Organization.- Noncoding RNAs as Therapeutic Targets.- Noncoding RNAs at H19/IGF2 Locus: Role in Imprinting, Gene Expression, and Associated Pathologies.

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