Abstract
Human Satellite II, a tandemly repeated stretch of DNA found near the centromeres of most human chromosomes, is not transcribed into RNA in normal human cells, but is expressed in many human cancer cell lines and tissues. HSATII transcripts accumulate in the nucleus adjacent to their sites of transcription and recruit nuclear regulatory proteins within these large nuclear foci. Recent evidence suggests that RNA and proteins within the nuclear environment can phase separate into liquid-like droplets, creating abberant structures, some of which are known to contribute to pathological effects.
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