Abstract
It was 2005 December. The distinguished speaker at the “Transcription Assembly” meeting at the Center for Cellular and Molecular Biology in Hyderabad was about to deliver his plenary lecture. We engaged ourselves in small talk with him. Since he had just arrived in the early hours of the day and probably had been traveling continuously to reach Hyderabad, an obvious opening question for the conversation was “How are you doing? You must have hardly got any sleep”. The answer came rather sharply “Well, it wasn’t too bad. Any way I sleep only for about four hours a day!” We listened to the marvelous exposition of the structure of one of the most complex and intriguing machines in biology, the eukaryotic RNA polymerase II by Prof. Roger Kornberg. Little did we know then that the very next year he was to receive the coveted Noble Prize in Chemistry for his work on elucidating the structure and function of RNA polymerase II!
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