Abstract
RNA-nucleoprotein (RNP) complexes are pivotal to the regulation of gene expression. These multiprotein, multifunctional complexes act as scaffolds, as molecular platforms, as hubs of interaction between the RNA and the proteins. The past decade has seen an exponential increase in the methodologies to identify and functionally characterize these complexes. In this review, we provide an overview of the recent advances in methodologies and the knowledge gained by characterizing these important complexes. This information has provided clues to the role of sequence, and structural determinants for RNA–Protein interaction networks in physiology and pathophysiology. With the recent studies implicating the role of RNA in the formation of biomolecular condensates, their role in health and disease warrants detailed sequence, structure and functional investigations.
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