Abstract
N6-methyladenosine (m6A) is a commonly modification of mammalian mRNAs and plays key roles in various cellular processes. Emerging evidence reveals the importance of RNA m6A modification in maintaining stem cell function in normal hematopoiesis and leukemogenesis. In this review, we first briefly summarize the latest advances in RNA m6A biology, and further highlight the roles of m6A writers, readers and erasers in normal hematopoiesis and acute myeloid leukemia. Moreover, we also discuss the mechanisms of these m6A modifiers in preserving the function of hematopoietic stem cells (HSCs) and leukemia stem cells (LSCs), as well as potential strategies for targeting m6A modification related pathways. Overall, we provide a comprehensive summary and our insights into the field of RNA m6A in normal hematopoiesis and leukemia pathogenesis.
Highlights
Hematopoietic homeostasis is maintained by rare multipotent hematopoietic stem cells (HSCs) via efficient self-renewal and differentiation into all lineage blood cells
We summarize the roles of m6A writers, readers and erasers in normal hematopoiesis and acute myeloid leukemia by focusing on their function in HSCs and leukemia stem cells (LSCs) maintenance, as well as potential strategies for targeting m6A modification related pathways
We found that ALKBH5 expression is regulated by chromatin state alteration during leukemogenesis of human Acute myeloid leukemia (AML), which is mediated by histone demethylase KDM4C
Summary
Hematopoietic homeostasis is maintained by rare multipotent hematopoietic stem cells (HSCs) via efficient self-renewal and differentiation into all lineage blood cells. The post-transcriptional modification of RNA plays important roles in regulating gene expression.
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