Abstract
Liquid-liquid phase separation (LLPS) has been demonstrated to be a key process in regulating cell compartmentalization. The emergence of phase-separated biomolecular condensates is effectively sustained by proteins with intrinsically disordered regions that can establish multiple homotypic self-interactions or heterotypic interactions with other biomolecules. Particularly, RNA-binding protein (RBP) phase separation has been shown to be critically regulated by RNA, and even though misregulation of LLPS is deeply connected to the onset of several neurodegenerative disorders such as Alzhemier, ALS, or even some types of cancer, the underlying molecular aspects remain hardly unclear.
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