Abstract
Window of opportunity: Using a single A-U to G-C mutation, the local and global dynamic characteristics of the transactivation response element (TAR) RNA was rationally altered over timescales extending up to milliseconds. This procedure allows it to mimic its bound state with the ligand argininamide (ARG). The mutant binds ARG with slightly enhanced affinity using a conformation indistinguishable from the wild-type sequence.
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