Abstract
RNA-binding proteins (RBPs) are critical regulators of transcriptional and posttranscriptional gene expression in eukaryotic organisms. The central role of these molecules in RNA metabolism has been clearly shown; however, the mechanisms involved in RNA cargo identification and selection are not clearly understood. The sequence and structure of RBPs as well as their target RNA molecules are essential to their ability to interact. However, it is clear that cellular context is also important to RBP–RNA association and the metabolic consequences of this association. This article discusses known interactions of RBPs and RNAs, the functional significance of these interactions, and methods available for their investigation.
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