Abstract
Ovarian cancer is one of the most lethal gynecologic malignancies for women. Due to the lack of efficient target therapy, the overall survival rate for patients with advanced ovarian cancer is still low. Illustrating the molecular mechanisms dictating ovarian cancer progression is critically important to develop novel therapeutic agents. Here, we found that RNA-binding motif protein 11 (RBM11) was highly elevated in ovarian cancer tissues compared with normal ovary, while RBM11 depletion in ovarian cancer cells resulted in impaired cell growth and invasion. Moreover, knockdown of RBM11 also retarded tumor growth in the A2780 ovarian cancer xenograft model. Mechanically, we found that RBM11 positively regulated Akt/mTOR signaling pathway activation in ovarian cancer cells. Thus, these results identify RBM11 is a novel oncogenic protein and prognostic biomarker for ovarian cancers.
Highlights
Ovarian cancer is one of the leading causes of death for gynecologic tumors among women, and more than 300,000 new ovarian cancer cases were diagnosed each year [1]
Human ovarian cancer cells A2780 and OVCAR-3 were obtained from the American Type Culture Collection (ATCC) and cultured in the Roswell Park Memorial Institute- (RPMI-) 1640 medium supplemented with 10% fetal bovine serum (FBS; Hyclone)
RNA-binding motif protein 11 (RBM11) Is Overexpressed in Ovarian Cancer Tissues
Summary
Ovarian cancer is one of the leading causes of death for gynecologic tumors among women, and more than 300,000 new ovarian cancer cases were diagnosed each year [1]. Understanding the mechanism for ovarian progression and identifying novel molecular switch that dictate ovarian cancer malignancy are critically important to develop novel treatments for this deadly disease. More than 2000 proteins have been identified to interact with RNA transcripts and are recognized as RBPs. RBPs are involved in various physiological and pathological processes including development, metabolism, proliferation, pluripotency, tumors, and immunity [9,10,11]. RBPs could exert either oncogenic or tumor suppression roles in different human cancers [12]. RNA-binding protein Nova and NELFE promote cancer growth in hepatocellular carcinoma (HCC) cells [13, 14], whereas RBM47 and RBM43 have been shown to suppress HCC growth [15, 16]
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