Abstract
BILE PLAYS an important role in facilitating the absorption of fat and cholesterol (Schonheimer, 1924) and some of the fat soluble vitamins (Greaves and Schmidt, 1933, 1937; Cohn and Schmidt, 1939) from the gastrointestinal tract. Hence it has generally been assumed that the same would be true of the steroid hormones and their derivatives. In fact bile or bile acids have been used to improve the oral activity of androgens both in experimental animals (Abarbanel, 1940, a) and in human patients (Abarbanel, 1939; 1940, b, c; Silberman et al., 1940). Although Wells et al. (1940) showed that in the rat the addition of desoxycholic acid does not enhance the oral effectiveness of testosterone propionate, they admitted that no generalizations can be made from their observations. It is evident that if an excess quantity of bile acids is given to an animal whose liver is already secreting a sufficient amount, an improvement in the absorption rate, is not to be expected.
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