Rituximab in the Treatment of Acquired Angioedema

Abstract

Acquired visceral angioedema is rare and has many causes including allergic, NSAID-induced, hereditary C1 esterase deficiency, acei-induced, acquired angioedema, and idiopathic angioedema. A sixty-one-year old woman with a history of C. difficile colitis s/p fecal transplant started to have severe abdominal pain and imaging-supported visceral angioedema over 1 year. Her GI specialist checked C4 and C1 esterase and noted deficiency of both. Patient was referred for evaluation of acquired angioedema and treatment.