Abstract
Immunoglobulin M (IgM) Nephropathy is a primary glomerulonephritis, characterized by predominant IgM deposition on direct immunofluorescence (DIF) microscopy. Long considered to be similar to minimal change disease (MCD) or focal segmental glomerulosclerosis (FSGS), it is now considered to be a separate entity with unique epidemiology, clinical presentation, biopsy findings, treatment response and prognosis. Although steroid is the first line treatment, there is a high degree of steroid resistance. Other immunosuppressive egents have not been quite effective. Rituximab is an emerging treatment option. We present a 40-year-old man with IgM Nephropathy in whom Rituximab proved to be a highly effective treatment.
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