Abstract
Abstract The strong acid‐promoted amidation of alcohol or olefin with nitrile is generally known as the Ritter reaction. It has been reported that some other types of molecules can also undergo this reaction under similar conditions by the formation of carbocations, such as trioxane, N ‐tosylazetidine, aziridine, oxirane, and epoxide. The outcome of this reaction depends on the reactivity of nitriles and the stability of carbocations. The study finds that the temperature may affect the reaction. Furthermore, it has been found that stereochemistry is completely retained in this reaction when a bromo group is present at the neighboring position. Various modifications of the original protocol of this reaction have been discussed. This reaction has very wide applications in organic synthesis.
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