Abstract
Many published case-control studies have investigated the association between rs12456492(A/G) variant in RIT2 gene and the risk of Parkinson's disease(PD); however, an ambiguous conclusion remains elusive. Our aim was to evaluate the association of RIT2 rs12456492(A/G) polymorphism with the risk of PD. We searched the Pubmed, Science Direct, EMBASE and EBSCO databases up to May 2015 for related studies. A total of 5 studies with 2541 PD cases and 2531 controls were included in the meta-analysis based on the strict inclusion and exclusion criteria. STATA 12.0 statistics software was used to calculate available data from each study. The pooled odds ratios (OR) and 95% confidence interval (CI) were calculated to assess the genetic association between RIT2 rs12456492 polymorphism and the risk of PD. There is a significant association between rs12456492 and PD (Gvs.A:OR=1.024, 95%CI:1.112–1.303, P=0.001; GGvs.AA:OR=1.486, 95%CI:1.259–1.755, P=0.001; GAvs.AA:OR=1.217, 95%CI:1.071–1.383, P=0.003; GG+GAvs.AA:OR=1.290, 95%CI:1.143–1.455, P=0.001; GGvs.GA+AA:OR=1.262, 95%CI:1.097–1.451, P=0.001). The data of our meta-analysis indicates that the G allele, GG and GA genotype of rs12456492(A/G) polymorphism may increase the risk of PD.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
