Abstract
Galactorrhea and amenorrhea are known risks of risperidone, given risperidone’s blockade of dopamine D2 receptors and subsequent risk of prolactin elevation, and this paper presents the case of an ...
Highlights
Galactorrhea and amenorrhea are known risks of risperidone, given risperidone’s blockade of dopamine D2 receptors and subsequent risk of prolactin elevation, and this paper presents the case of an adolescent female patient who developed reversible amenorrhea and galactorrhea after being treated with risperidone 0.25 mg twice a day for three months
Since the late 1970s it has been known that neuroleptics can raise prolactin levels due to their dopamine antagonist action (Sachar, Gruen, Altman, & Frantz, 1976)
This patient did not have elevated levels of prolactin, her case must be placed in the context of the available literature of risperidone’s effect on the tuberoinfundibular pathway and associated side effects
Summary
Galactorrhea and amenorrhea are known risks of risperidone, given risperidone’s blockade of dopamine D2 receptors and subsequent risk of prolactin elevation, and this paper presents the case of an adolescent female patient who developed reversible amenorrhea and galactorrhea after being treated with risperidone 0.25 mg twice a day for three months. In this paper a case of the latter is reported, though with the unusual feature of prolactin levels remaining normal. Past treatment of these conditions included quetiapine, which had no effect, and aripiprazole, which increased the patient’s aggression.
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