Abstract

This is a copy of an article published in the Cochrane Database of Systematic Reviews © 2016 Cochrane Collaboration Publications. © The Author(s). http://www.cochranelibrary.com/

Highlights

  • Risperidone is the first new generation antipsychotic drug made available in a long-acting injection formulation

  • People already stabilised on oral risperidone may continue to maintain benefit if treated with depot risperidone and avoid the need to take tablets, at least in the short term

  • In people who are happy to take oral medication the depot risperidone is approximately equal to oral risperidone

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Summary

Introduction

Risperidone is the first new generation antipsychotic drug made available in a long-acting injection formulation. Antipsychotic drugs are effective for treating acute episodes and for preventing relapse (Davis 1977; Davis 1986) These drugs are usually given orally, but compliance is poor and ranges from 20% to 89% with an average of 50% (Fenton 1997; Young 1986). This means that, on average, half the patients treated with these drugs will not comply with prescribed medication. This is probably due to a combination of various factors such as the erosion of insight that accompanies psychotic illnesses, adverse effects and human nature

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