Abstract
On December 29, 1993, the Food And Drug Administration approved the new antipsychotic agent risperidone (Risperdal) for use in the United States. Risperidone is the first of a new class of antipsychotic agents known as serotonin/dopamine antagonists. It is only the second new antipsychotic medication to be introduced in this country during the past two decades. Early efficacy studies show that risperidone has marked superiority in reducing both positive and negative symptoms over placebos and haloperidol. Risperidone does not produce the blood dyscrasias associated with clozapine and possesses a relatively dean adverse reaction profile. Maximum therapeutic responses have been observed with doses of 4 mg to 8 mg; higher dosages have resulted in extrapyramidal symptoms without added benefits.
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