Abstract
In Reply.— We are grateful to the Drs Hecht for their stimulating comments on our paper and appreciate their criticisms. The purist approach of eliminating data because of `bias of ascertainment' is admired, but it is hard for clinicians to offer the suggestion of an 8% risk when the two confirmed carriers who have had offspring have a total of 10 pregnancies between them resulting in one healthy girl, two spontaneous abortions, one carrier status, and six cases of `Typus Edinburgensis.'
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