Abstract
Investigators at Lurie Children's Hospital of Chicago; Mayo Clinic, Rochester, MN; and centers in Connecticut, the Netherlands and Nova Scotia, pooled data from 4 large pediatric cohorts and obtained direct estimates of the mortality risk overall and from specific causes of mortality, particularly seizure related SUDEP.
Highlights
Of 13 deaths related to seizures 10 (77%) were attributed to SUDEP
Risk of SUDEP varies with age and is higher in adults
In a recent prospective study of 245 children with childhood-onset epilepsy followed for almost 40 years, 60 subjects had died, and 33 (55%) deaths were epilepsyrelated including SUDEP in 23/60 (38%), status epilepticus in 4 (7%), and accidental drowning in 6 (10%)
Summary
Investigators at Lurie Children’s Hospital of Chicago; Mayo Clinic, Rochester, MN; and centers in Connecticut, the Netherlands and Nova Scotia, pooled data from 4 large pediatric cohorts and obtained direct estimates of the mortality risk overall and from specific causes of mortality, seizure related SUDEP. Of 2239 subjects followed for >30,000 person-years, 79 died at average age of 11.6 y, an overall-death rate of 228 per 100,000PY (10 with neurometabolic disorders were excluded). The death rate in the complicated group of epilepsies (743 per 100,000) was higher than in the uncomplicated group (36 per 100,000) (P
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