Risks for obesity-associated diseases and conditions

Abstract

Alimentary-constitutional obesity is a chronic heterogeneous multifactorial disorder, the relevance of which can hardly be overestimated. The severe forms of this disorder are accompanied by specific complications, a high cardiometabolic risk, and obesity-related comorbidities. Objective. To study obesity-associated diseases and conditions. Subjects and methods. The investigation involved 426 overweight and obese patients. They underwent an examination that included historical data collection; physical examination for estimation of the severity of obesity and the grade of hypertension; abdominal ultrasound for diagnosis of hepatic steatosis or non-alcoholic fatty liver disease (NAFLD), and laboratory testing for a study of the parameters of carbohydrate and fat metabolisms and liver function. Results. Patients with severe alimentary-constitutional obesity had a higher risk of comorbidity: the risk of hypertension was elevated by 3.5-fold, type 2 diabetes mellitus and impaired glucose tolerance by 5-fold, metabolic syndrome by 4-fold, and NAFLD by 5.5-fold. Conclusion. Severe alimentary-constitutional obesity is a risk factor for comorbidity. At the same time, the solution of losing weight is a complex task to physicians of various specialties and consists of measures in both public health and patient commitment to a healthy lifestyle.