Risk to Developing Germ Cells from Hormonal Treatment of Cryptorchidism

Abstract

Urology| July 01 2000 Risk to Developing Germ Cells from Hormonal Treatment of Cryptorchidism AAP Grand Rounds (2000) 4 (1): 2–3. https://doi.org/10.1542/gr.4-1-2 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Risk to Developing Germ Cells from Hormonal Treatment of Cryptorchidism. AAP Grand Rounds July 2000; 4 (1): 2–3. https://doi.org/10.1542/gr.4-1-2 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search nav search search input Search input auto suggest search filter All PublicationsAll JournalsAAP Grand RoundsPediatricsHospital PediatricsPediatrics In ReviewNeoReviewsAAP NewsAll AAP Sites Search Advanced Search Topics: cryptorchidism, germ cells, testis Source: Cortes D, Thorup J, Visfeldt, J. Hormonal treatment may harm the germ cells in 1- to 3-year-old boys with cryptorchidism. J Urol. 2000;163:1290–1292. Nearly 3% of boys in the western world undergo surgery to correct cryptorchidism. Hormonal treatment of cryptorchidism with HCG (human chorionic gonadotrophin) or GNRH (gonadotrophin releasing hormone)distinguishes retractile testes from true undescended testes and causes testicular descent in about 20% of boys.1 Normally, from the age of 9 months through later in childhood gonadotrophin and testosterone levels are suppressed and there is a slow maturation of the germinal layer of the testes. Biopsy of the testes from the age of 1–3 years reveals a small number of spermatogonia or germ cells developing within the tubules. A very low number of germ cells in the child’s testes are somewhat predictive of future fertility. The Danish authors asked if exposure to... You do not currently have access to this content.