Abstract
AimTo estimate the pooled prevalence and incidence of suicidal ideation, attempts, and deaths in people with sleep apnea.MethodWe will identify epidemiological studies reporting the prevalence or incidence rate of suicide in people with sleep apnea. We will search the following databases: PubMed (MEDLINE), Scopus, Cochrane Library, OVID (HEALTH STAR), OVID (MEDLINE) and Joana Briggs Institute EBF Database. No age, geographical location, study-design or language limits will be applied. This protocol was developed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) guidelines. Two reviewers (YY and YP) will independently screen citations, abstracts and will identify full-text articles for inclusion, extract data, and appraise the quality and bias of included studies. Discrepancies will be resolved by consulting with a third researcher (MC). Study quality will be assessed by the Newcastle-Ottawa Scale. The primary outcomes will be the overall prevalence or incidence of suicidal ideation, attempts and completion and the risk of suicide in people with sleep apnea. For pooling of the studies, we will use a random-effects model with a logit transformation. The DerSimonian and Laird (DL) random-effects method will be used to estimate the pooled inter-study variance. We will assess the between-study heterogeneity using I2 statistics, and Cochrane’s Q statistic (significance level < 0.05). If the I2 is high (>75%), we will perform subgroup meta-analyses and conduct a meta-regression analysis to explore sources of study heterogeneity using study level median age, study-level proportions of race, gender, depression and quality scores. We will report effect estimates as suicide risk per 1000 individuals. Egger’s test and funnel plots will be used to assess publication bias, and adjusted estimates using trim and fill methods will be reported if publication bias is suspected.Ethics and disseminationNo ethics clearance is required as no primary data will be collected. The results of this systematic review and meta-analysis will be presented at scientific conferences and published in a peer-review journal. The results may shed more light on the burden of suicide risk among individuals with sleep apnea and may guide future population-specific interventions.Trial registrationPROSPERO registration number: CRD42020165404.
Highlights
Sleep apnea is a potentially serious sleep disorder in which breathing is briefly and repeatedly interrupted during sleep [1]
In the United States, it is estimated that 26% of adults aged 30–70 live with sleep apnea, and more than 25 million adults suffer from Obstructive sleep apnea (OSA) [3]
The objective of this study is to present a protocol for review and meta-analysis to ascertain the prevalence or incidence of suicidal ideation, attempt, and completion in sleep apnea and to delineate additional risk factors that may explain the high prevalence of suicide risk in individuals with sleep apnea
Summary
Sleep apnea is a potentially serious sleep disorder in which breathing is briefly and repeatedly interrupted during sleep [1]. In the United States, it is estimated that 26% of adults aged 30–70 live with sleep apnea, and more than 25 million adults suffer from OSA [3]. According to the 2005–2014 National Survey among the United States male veterans, the prevalence of sleep apnea increased from 3.7% to 8.1% (p-value for trend
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
