Abstract
Stomach cancer is a widespread health condition associated with environmental and genetic factors. Contribution of ionizing radiation to stomach cancer etiology is not sufficiently studied. This study was aimed to assess an association of the stomach cancer incidence risk with doses from occupational radiation exposure in a cohort of workers hired at main Mayak production association facilities in 1948–1982 taking into account non-radiation factors including digestive disorders. The study cohort comprised 22,377 individuals and by 31.12.2013 343 stomach cancer diagnoses had been reported among the cohort members. Occupational stomach absorbed doses were provided by the Mayak Worker Dosimetry System– 2008 (MWDS–2008) for external gamma ray exposure and by the Mayak Worker Dosimetry System– 2013 (MWDS–2013) for internal exposure to plutonium. Excess relative risks (ERR) per Gy for stomach cancer were estimated using the Poisson’s regression. Analyses were run using the AMFIT module of the EPICURE software. The stomach cancer incidence risk in the study cohort was found to be significantly associated with the stomach absorbed dose of gamma rays: ERR/Gy = 0.19 (95% CI: 0.01, 0.44) with a 0 year lag, and ERR/Gy = 0.20 (95% CI: 0.01, 0.45) with a 5 year lag. To estimate the baseline risk, sex, attained age, smoking status and alcohol consumption, chronic diseases (peptic ulcer, gastritis and duodenitis) were taken into account. No modifications of the radiogenic risk by non-radiation factors were found in the study worker cohort. No association of the stomach cancer incidence risk with internal exposure to incorporated plutonium was observed.
Highlights
Stomach cancer (StoCa) remains one of the most frequent malignant neoplasms despite decreasing incidence and mortality rates observed during recent decades in many countries [1]
The best fit of baseline StoCa data was provided by the model that took into account the following parameters: attained age, smoking status, alcohol consumption, stomach and duodenal ulcer, chronic gastritis and duodenitis (SmSta-adj model)
The ERRed/Gy estimated relative to the background risk taking into account sex, attained age, smoking status, alcohol consumption and chronic digestive diseases was comparable to estimates provided by previous studies of the cohort
Summary
Stomach cancer (StoCa) remains one of the most frequent malignant neoplasms despite decreasing incidence and mortality rates observed during recent decades in many countries [1]. StoCa is a polyetiological disease that develops as a result of a complex interaction of environmental factors and the level of the effect of this interaction considerably depends on genetically determined features of an organism. Helicobacter pylori (H. pylori) infection, unhealthy diet, smoking, alcohol consumption have been recognized to be main risk factors for StoCa [2,3,4,5,6].
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