Abstract
S-29C6-3 Background/Aims: Recent findings suggest that exposure to disinfection by-products may increase the risk of stillbirth. The results of these studies are inconsistent, but warrant further attention. Methods: To assess the effect of water chlorination by-products on stillbirth, we conducted a population-based case-control study of 3289 cases of stillbirth and a random sample of 32,890 control subjects from 396,049 Taiwanese newborns in 2001–2003 using information from the Birth Registry and Waterworks Registry in Taiwan. We compared the risk of stillbirth in 4 disinfection by-product exposure categories based on the levels of total trihalomethanes (TTHMs) representing high (TTHMs 20+ μg/L), medium (TTHMs 10–19 μg/L), low exposures (TTHMs 5–9 μg/L), and 0–4 μg/L as the reference category. Results: In logistic regression analysis adjusting for gender, maternal age, plurality, conception of season, and population density of the municipality where the mother lived during pregnancy, the odds ratio for stillbirth was 1.10 (95% CI: 1.00–1.21) for medium exposure and 1.06 (95% CI: 0.96–1.17) for high exposure compared to reference category. Conclusion: The risk of stillbirth may associate with women exposure to disinfection by-products in Taiwanese drinking water.
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