Abstract
Vitiligo is a chronic disorder causing skin depigmentation with around 1% global prevalence, affecting people of all ages, skin types and genders.1 Due to the absence of melanin in lesional skin there is a theoretical concern that there might be a higher risk of skin cancer in people with vitiligo. However, some studies have shown that the genetic and autoimmune profiles of vitiligo patients may confer a degree of protection against the development of melanoma and non‐melanoma skin cancer (NMSC).2 Therefore, the aim of this systematic review was to quantify the risk of skin cancer (melanoma and NMSC) in people with vitiligo compared to those without vitiligo.
Highlights
Vitiligo is a chronic disorder causing skin depigmentation with around 1% global prevalence, affecting people of all ages, skin types and genders.[1]
Details of the search strategy and the PRISMA flow diagram are available on request to the corresponding author
The meta-analyses for non-melanoma skin cancer (NMSC) and melanoma combined results from three studies each[3,4,5,8] which included a total of 11,447 and 11,366 people with vitiligo, respectively The two studies excluded from the meta-analysis found no events of skin cancer in either vitiligo nor non-vitiligo groups (366 patients excluded).[6,7]
Summary
Vitiligo is a chronic disorder causing skin depigmentation with around 1% global prevalence, affecting people of all ages, skin types and genders.[1]. A total of 2,177 studies were identified, of which 12 full text articles were assessed for eligibility. Five studies were eligible to be included in the review. Of the six studies included in the review, four were included in the meta-analysis.
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