Abstract
The aim of this retrospective, nationwide, matched cohort study was to investigate the association of serous retinal detachment with having end-stage renal disease (ESRD) while on dialysis. The cohort study included 94,024 patients with ESRD on dialysis registered between January 2000 to December 2009 in the Taiwan National Health Insurance Research Database. An age- and sex-matched control group comprised 94,024 patients selected from the Taiwan Longitudinal Health Insurance Database 2000. Information for each patient was collected from the index date until December 2011. Twenty-seven ESRD patients and 11 controls developed serous retinal detachment (P < 0.001) during follow-up, demonstrating a significantly increased risk of serous retinal detachment in patients with ESRD on dialysis compared with controls (incidence rate ratio = 3.39, 95% confidence interval [CI] = 1.68–6.83). After adjustment for potential confounders, patients were 3.86 times more likely to develop serous retinal detachment than the full cohort (adjusted HR = 3.86, 95% CI = 1.15–12.96). In conclusion, patients with ESRD on dialysis demonstrate an increased risk of serous retinal detachment. Interdisciplinary collaboration between nephrologists and ophthalmologists is important to deal with serous retinal detachment in patients with ESRD on dialysis and prevent impairments of visual acuity.
Highlights
End-stage renal disease (ESRD), the most severe form of chronic kidney disease, is known as a worldwide public health problem
We classified the patients with ESRD on dialysis into HD and peritoneal dialysis (PD) groups based on the different treatment modalities, finding that of the 94,024 patients with ESRD on dialysis, 83,764 (89.09%) received HD and 10,260 (10.91%) received PD (Table 1)
The Kaplan–Meier survival analyses revealed higher serous retinal detachment cumulative incidence rates in the patients with ESRD on dialysis than in the control patients, and the logrank test was significant (P
Summary
End-stage renal disease (ESRD), the most severe form of chronic kidney disease, is known as a worldwide public health problem. ESRD often requires dialysis or kidney transplantation because of the poor prognosis owing to morbidity and mortality [1,2,3]. Serous retinal detachment and end-stage renal disease. Taiwan has the highest incidence and prevalence of patients with ESRD on dialysis [6,7,8]. The association between ESRD and many retinal diseases, such as retinal artery occlusion, retinal vein occlusion, or age-related macular degeneration, has been demonstrated by several reports recently [9,10,11]
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