Abstract
The risk of a first seizure, subsequent seizures, and neurodevelopmental disability following the administration of diphtheria and tetanus toxoids and whole-cell pertussis (DTP) vaccine and measles, mumps, and rubella (MMR) vaccine was studied by a retrospective review of children’s medical records at four health maintenance organizations, including University of Washington, Seattle; and Kaiser Permanente Groups in OR and CA, members of the CDC & P Vaccine Safety Datalink Project.
Highlights
The risk of a first seizure, subsequent seizures, and neurodevelopmental disability following the administration of diphtheria and tetanus toxoids ana whole-cell pertussis (DTP) vaccine and measles, mumps, and rubella (MMR) vaccine was studied by a retrospective review of children's medical records at four health maintenance organizations, including University of Washington, Seattle; and Kaiser Permanente Groups in OR and CA, members of the CDC & P Vaccine Safety Datalink Project
Nonfebrile seizures occurred within 30 days after DTP and MMR vaccines in 10 and 3 children, respectively
Pediatric Neurology Briefs 2001 seizures associated with vaccination did not carry a higher risk of subsequent epilepsy or neurodevelopmental disabilities (ADHD, learning disorders, retardation, infantile autism, other emotional and behavior disorders) than nonvaccine related febrile seizures
Summary
RISK OF SEIZURES FOLLOWING DTP AND MMR VACCINES The risk of a first seizure, subsequent seizures, and neurodevelopmental disability following the administration of diphtheria and tetanus toxoids ana whole-cell pertussis (DTP) vaccine and measles, mumps, and rubella (MMR) vaccine was studied by a retrospective review of children's medical records at four health maintenance organizations, including University of Washington, Seattle; and Kaiser Permanente Groups in OR and CA, members of the CDC & P Vaccine Safety Datalink Project. Following 340,386 DTP and 137,457 MMR vaccinations, 2281 first seizures were identified using automated data, and 716 first seizures from random sampling and chart review of 1094 children.
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