Abstract
IntroductionA retrospective registry-based cohort study was conducted to examine the risk of second primary cancer following the occurrence of breast cancer in males.MethodsData obtained from the California Cancer Registry in the period 1988 to 2003 included 1,926 men aged 85 years and younger diagnosed with a first primary breast cancer. Person-year analysis was applied to determine the risk of second primary cancers after the occurrence of a first primary breast cancer. The effects of age, race, and time since the first breast cancer diagnosis were assessed.ResultsOf the 1,926 male breast cancer cases, 221 (11.5%) developed a second primary cancer. Men with first incidence of breast cancer have a significantly higher risk of second cancer (standardized incidence ratio (SIR) = 1.16, 95% confidence interval (CI) = 1.01–1.32). The risk of a second site-specific cancer is elevated for breast cancer (SIR = 52.12, 95% CI = 31.83–80.49), cutaneous melanoma (SIR = 2.98, 95% CI = 1.63–5.00) and stomach cancer (SIR = 2.11, 95% CI = 1.01–3.88). There is a general tendency towards higher risks of second malignancies among younger men compared to older men and the risk increased with the passage of time.ConclusionMale breast cancer patients should be monitored carefully for the occurrence of second primary cancers, especially a second primary breast cancer.
Highlights
A retrospective registry-based cohort study was conducted to examine the risk of second primary cancer following the occurrence of breast cancer in males
Data obtained from the California Cancer Registry in the period 1988 to 2003 included 1,926 men aged 85 years and younger diagnosed with a first primary breast cancer
The risk of a second site-specific cancer is elevated for breast cancer (SIR = 52.12, 95% confidence interval (CI) = 31.83–80.49), cutaneous melanoma (SIR = 2.98, 95% CI = 1.63–5.00) and stomach cancer (SIR = 2.11, 95% CI = 1.01– 3.88)
Summary
A retrospective registry-based cohort study was conducted to examine the risk of second primary cancer following the occurrence of breast cancer in males. The diagnosis of a rare cancer or cancer in the less usually affected sex, for example, male breast cancer (MBC), may indicate hereditary cancer risk [3]. Auvinen and colleagues [5] utilized the National Cancer Institute's Surveillance and Epidemiology End Results (SEER) data for 1,788 men and found a 30-fold excess risk of a second breast cancer and a 2-fold excess risk of cutaneous melanoma. An excess risk of second primary malignancy affecting the small intestine, rectum, pancreas, lymphohematopoietic system, prostate, and non-melanoma skin was elucidated [6]. The present study will attempt to confirm these findings and examine the relationships between observed multiple primaries, which may indicate a common etiology
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