Abstract
The purpose of this study was to evaluate the effects of long-term oral antihypertensive treatment using centrally acting sympatho-inhibitory drugs (clonidine) and beta-blockers (metoprolol) on capillary microcirculation in the labial and periodontal mucosa. Sixty subjects were recruited for the study: 20 patients affected by hypertension in treatment with centrally-acting sympatho-inhibitory drugs (64.28 ± 11.78 years); 20 patients in treatment with beta-blockers (62.03 ± 9.84 years) and 20 healthy subjects (62.06 ± 6.72 years). We use the videocapillaroscopic technique to evaluate in vivo the microcirculation of the labial mucosa corresponding to the lower lip and of the periodontal mucosa corresponding to the central superior incisor. Capillaroscopy revealed a significant increase in the length, diameter, tortuousity and density (P <0.05) of capillaries in patients affected by hypertension in treatment with centrally acting sympatho-inhibitory drugs, while beta-blockers had a lower effect on the labial and periodontal microcirculation compared to the healthy population. The capillaroscopic has revealed substantial modifications of the oral microcirculatory pattern in hypertensive patients in treatment with centrally-acting sympatho-inhibitory drugs than with beta-blockers.
Highlights
The purpose of this study was to evaluate the effects of long-term oral antihypertensive treatment using centrally acting sympatho-inhibitory drugs and beta-blockers on capillary microcirculation in the labial and periodontal mucosa
In our study we evaluated the effect of different antihypertensive drugs on capillary microcirculation in the labial and periodontal mucosa
We evaluated if there exist a correlation between the types of antihypertensive drug, the characteristic of microcirculation and the eventual risk of periodontitis
Summary
The purpose of this study was to evaluate the effects of long-term oral antihypertensive treatment using centrally acting sympatho-inhibitory drugs (clonidine) and beta-blockers (metoprolol) on capillary microcirculation in the labial and periodontal mucosa. Considering that the principal role of microcirculation is that of providing for the needs of tissue in terms of the exchange of oxygen and nourishments, these modifications cause the tissue to suffer until damaging the organ[5]. It has been shown how some antihypertensive drugs such as centrallyacting antihypertensive drugs can reduce hypertension and the negative effects correlated to it. Some researchers have demonstrated that the arterial pressure-lowering effect induced by chronic oral antihypertensive treatment with drugs from different pharmacological classes is not always accompanied by the same reversion in functional and structural capillary rarefaction
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