Abstract
The risk of osteoporosis in patients with chronic inflammatory neuropathy (CIN) has not been evaluated in detail. We conducted a population-based case-control study nested in a retrospective cohort to analyze osteoporosis risk among patients with CIN using a nationwide database. Patients with CIN based on the Korean Classification of Disease diagnostic code were included and were matched to controls. A Cox proportional hazards regression model was used to evaluate the effect of CIN on osteoporosis. After propensity score matching, 585 CIN patients and 585 controls were selected. Patients with CIN had an increased osteoporosis risk (hazard ratio [HR] = 2.293, 95% confidence interval [CI] 1.460–3.601) compared with controls. The osteoporosis risk was higher among male patients with CIN than among male controls (HR = 5.404, 95% CI 2.252–12.969), while there were no significant differences among women. Among the CIN patients, the average daily dose of corticosteroids was higher in those who developed osteoporosis (19.6 mg [10.8–49.3]) than those who did not (16.2 mg [7.2–29.1], p = 0.001). The osteoporosis risk among CIN patients is higher than among controls. High risk of osteoporosis in male patients may indicate that osteoporosis in CIN patients results from the disease itself or related treatments.
Highlights
Chronic inflammatory neuropathy (CIN), which includes chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and multifocal motor neuropathy (MMN), is a rare immune-mediated disease of the peripheral nerves that shows a progressive clinical course[1,2,3]
585 patients with chronic inflammatory neuropathy (CIN) and 585 controls were used in the analysis and it was confirmed that there were no significant differences in age, sex, and Charlson comorbidity index (CCI) scores between the 2 groups
The risk of osteoporosis was significantly higher among male patients with CIN than among male controls (HR = 5.404, 95% CI 2.252–12.969)
Summary
Chronic inflammatory neuropathy (CIN), which includes chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and multifocal motor neuropathy (MMN), is a rare immune-mediated disease of the peripheral nerves that shows a progressive clinical course[1,2,3]. Not as severe as in CIDP, MMN can present with lower limb weakness and more than half of patients display abnormal gait before treatment[6]. Only a few studies with small study populations have assessed the risk of osteoporosis among patients with CIN, and there is a lack of comprehensive analyses of the effect of each risk factor on osteoporosis. This could be due to the low prevalence of CIN, which ranges from 1 to 4.8 per 100,000 for CIDP and 1–2 per 100,000 for MMN10–14. We analyzed the occurrence of osteoporosis in patients with CIN using a nationwide database
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
