Risk of Nonsyndromic Cleft Lip and Palate in Relatives of Women With Breast Cancer

Abstract

Nonsyndromic cleft lip and/or cleft palate (NSCL/P, OMIM119530) is the most common craniofacial birth defect. Epidemiological studies have assessed the relationship between cancer and NSCL/P. This study determined the frequency of NSCL/P in families of women with breast cancer (BC). Five hundred thirty-eight women (246 with BC and 292 without BC) were evaluated. Women from both groups completed a questionnaire concerning their family history of NSCL/P in first-degree relatives. We used chi-square and Fisher's exact tests to determine statistically significant differences between both groups of women (α = 0.05). From the 246 women with BC, two had a positive history of NSCL/P; in the control group, two women had a history of NSCL/P (chi-square with 1 degree of freedom, p = 0.86; Fisher's test, p = 0.37). Thus the frequency of NSCL/P was not significantly increased in the first-degree relatives of women with BC. Acknowledgment: FAPEMIG.