Abstract
Sleep disorders pose a serious threat to human, which may cause variety diseases. Recent reviews on the epidemiology examine that gastroesophageal reflux disease (GERD) has different levels of causality about asthma, chronic dry cough, sleep apnea, non-cardiac chest pain, chest tightness, and chronic bronchitis. The relationship between sleep disorders and GERD has been explained in various ways, but only limited reports on the complication rates in Taiwan. The objective of this follow-up study is to evaluate the risk of incident GERD in Taiwanese people with sleep disorders from January 1, 2000 to December 31, 2012. We used the Taiwan’s National Health Insurance Research Database to conduct a nationwide population-based cohort study to assess the risk of incident GERD in people with sleep disorders. A total of 66,133 sleep disorders patients and 264,532 non-sleep disorders controls were included. Sleep disorders was a risk factor of incident GERD (adjusted hazard ratio being 1.722, 95% CI 1.69–1.76, p < 0.001) after controlling potential confounders including age, sex, comorbidities, and hiatal hernia. In conclusion, sleep disorders might be a risk factor for development of GERD based on the 12-year follow-up.
Highlights
Sleep disorders pose a serious threat to human, which may cause variety diseases
Recent reviews on the epidemiology examines that gastroesophageal reflux disease (GERD) have different levels of causality about asthma, chronic dry cough, sleep apnea, non-cardiac chest pain, chest tightness, chronic bronchitis
The objective of this study is to evaluate the risk of incident gastroesophageal reflux disease (GERD) in Taiwanese people with sleep disorders
Summary
Recent reviews on the epidemiology examines that gastroesophageal reflux disease (GERD) have different levels of causality about asthma, chronic dry cough, sleep apnea, non-cardiac chest pain, chest tightness, chronic bronchitis. GERD is defined as a condition that develops when the reflux of stomach contents causes troublesome symptoms or complications, is a common chronic disorders prevalent in many countries [11] It is associated with a huge economic burden in the western countries and significantly decreased quality of life [12]. Recent reviews on the epidemiology examines that GERD have different levels of causality about asthma, chronic dry cough, sleep apnea, non-cardiac chest pain, chest tightness, chronic bronchitis [13, 14]. Some studies even show that chronic life stress and psychological disturbances, such as depression, anxiety, and somatization increase their symptoms [16, 17]
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