Abstract
6633 Background: Radiation therapy (XRT) including radioisotopes (RI), radioactive implants (RAI) and external beam radiation (EBRT) are commonly used for treatment of well differentiated thyroid malignancies (WDTMs) – papillary and follicular. We investigated the risk of all secondary hematologic malignancies (SHMs) in a population-based cohort of patients (pts) with WDTMs treated with XRT. Methods: Surveillance, Epidemiology, and End Results (SEER) 17 registries were queried to identify a cohort of 52,121 adult pts with WDTM as the first primary cancer between 1/1973 and 12/2010 who had adequate follow up. To determine the risk of development of SHM at least one year after the diagnosis of WDTM, pts who received XRT were compared to those who did not. SHMs included leukemias, lymphomas and Multiple Myeloma (MM). Fine and Gray competing risk regression analysis was performed with SHM as a time-dependent endpoint and death from any cause, development of non-hematologic malignancy as the competing events. ...
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