Abstract
BackgroundDiabetes mellitus (DM) has been associated with the cancer risk. This study investigated relationship between DM and esophageal cancer using Taiwan’s insurance data.MethodsWe identified 549 patients with esophageal cancer newly diagnosed in 2000-2009 and randomly selected 2196 controls without any cancer, frequency matched by sex, age and diagnosis year of cases. Logistic regression model estimated odds ratios (ORs) and 95% confidence intervals (CI) of esophageal cancer associated with DM, sex, age. co-morbidities and medications.ResultsCases were more prevalent than controls for alcoholism and esophageal disorders and using nonsteroidal anti-inflammatory drugs (NSAIDs) and cyclooxygenase-2 inhibitors but not DM. Esophageal cancer had no association with DM (OR 0.99, 95% CI 0.71-1.37), but significantly associated with alcoholism (OR 14.1, 95% CI 7.87-25.4), esophageal ulcer (OR 10.1, 95% CI 5.70-17.9), esophageal reflux (OR 3.47, 95% CI 2.14-5.26) and uses of NSAIDs (OR 2.73, 95% CI 1.80-4.13). An elevated risk of esophageal cancer appeared in DM patients taking insulin (OR 2.57, 95% CI 1.08-6.15) or sulfonyurea (OR 3.80, 95% CI 1.16-12.5).ConclusionsPatients with DM are not at higher risk for esophagus cancer. However, esophageal disorders and anti-diabetic drugs are associated with the risk of the disease.
Highlights
Diabetes mellitus (DM) has been associated with the cancer risk
Glucose metabolism disorders (GMDs) such as diabetes mellitus (DM), impaired fasting glucose regulation (IFG), impaired glucose intolerance (IGT), and hypoglycemia are systemic diseases that have been associated with many other diseases including malignancy [1]
Cases were more prevalent with co-morbidities of alcoholism, esophageal ulcer, esophageal reflux, and COX-2 inhibitors except use of other nonsteroidal anti-inflammatory drugs (NSAIDs)
Summary
Diabetes mellitus (DM) has been associated with the cancer risk. Studies have associated DM with increased risk of cancers, such as esophageal cancer, hepatocellular carcinoma, bladder cancer, kidney cancer, Esophagus cancer incidence has been rising rapidly in many countries [12,13,14,15,16]. Population in Taiwan has exactly the other type of esophageal cancer; approximately 95% patients have the squamous cell carcinoma [18]. The association between squamous cell carcinoma and DM in the Taiwan population may be different from that between adenocarcinoma and DM in the Western populations.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
