Abstract
BackgroundNonalcoholic fatty liver disease (NAFLD) and metabolic dysfunction associated fatty liver disease (MAFLD) have important associations with cardiovascular disease (CVD). The main objective of this study was to compare the frequency of incidence rate of CVD in the NAFLD or MAFLD patients utilizing a large claims database.MethodsUsing the JMDC database from April 2013 to March 2019, we retrospectively analyzed data for 1,542,688 and 2,452,949 people to estimate the relationship between CVD and NAFLD, MAFLD, respectively.ResultsThe incidence rates of CVD were 0.97 (95% CI 0.94–1.01) and 2.82 (95% CI 2.64–3.01) per 1000 person-years in the non-NAFLD and NAFLD groups, respectively, and 1.01 (95% CI 0.98–1.03) and 2.69 (95% CI 2.55–2.83) per 1000 person-years in the non-MAFLD and MAFLD groups, respectively. The overall prevalence of hypertriglyceridemia and diabetes mellitus (DM) was 13.1, and 4.2%, respectively, in the non-NAFLD group and 63.6, and 20.2%, respectively, in the NAFLD group. The overall prevalenceof hypertriglyceridemia and DM was 13.6 and 4.3%, respectively, in the non-MAFLD group and 64.1, and 20.6%, respectively, in the MAFLD group. HRs for CVD increased with hypertriglyceridemia and DM.ConclusionsResults indicated that incident rate of CVD increased with NAFLD/MAFLD; the complication rate of DM and hypertriglyceridemia among NAFLD/MAFLD patients is high and may affect the development of CVD.
Highlights
MethodsNon-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide with a global prevalence of 25.2% and a prevalence of 29.6% in Asia [1, 2]
HRs for cardiovascular disease (CVD) increased with hypertriglyceridemia and diabetes mellitus (DM)
Results indicated that incident rate of CVD increased with Nonalcoholic fatty liver disease (NAFLD)/metabolic dysfunction associated fatty liver disease (MAFLD); the complication rate of DM and hypertriglyceridemia among NAFLD/MAFLD patients is high and may affect the development of CVD
Summary
MethodsNon-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide with a global prevalence of 25.2% and a prevalence of 29.6% in Asia [1, 2]. Fatty liver caused by nutritional metabolic disorders regardless of other chronic liver diseases has been proposed as a new liver disease concept, ‘‘metabolic dysfunction associated fatty liver disease (MAFLD)‘‘ [4]. Cardiovascular disease (CVD) has been reported as the most important cause of death, followed by non-liver malignancy and complications of cirrhosis (along with hepatocellular carcinoma and liver transplantation) in NAFLD patients [5, 6]. Multiple reports have indicated that NAFLD might have had important associations with cardiovascular outcomes in the past decade [9, 10]. Some reports have shown that MAFLD correlates more strongly with CVD than NAFLD [11, 12]. Nonalcoholic fatty liver disease (NAFLD) and metabolic dysfunction associated fatty liver disease (MAFLD) have important associations with cardiovascular disease (CVD). The main objective of this study was to compare the frequency of incidence rate of CVD in the NAFLD or MAFLD patients utilizing a large claims database
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