Abstract
We investigated the risk of cancer mortality according to obesity status and metabolic health status using sampled cohort data from the National Health Insurance system. Data on body mass index and fasting blood glucose in the sampled cohort database (n=363,881) were used to estimate risk of cancer mortality. Data were analyzed using a Cox proportional hazard model (Model 1 was adjusted for age, sex, systolic blood pressure, diastolic blood pressure, total cholesterol level and urinary protein; Model 2 was adjusted for Model 1 plus smoking status, alcohol intake and physical activity). According to the obesity status, the mean hazard ratios were 0.82 [95% confidence interval (CI), 0.75-0.89] and 0.79 (95% CI, 0.72-0.85) for the overweight and obese groups, respectively, compared with the normal weight group. According to the metabolic health status, the mean hazard ratio was 1.26 (95% CI, 1.14-1.40) for the metabolically unhealthy group compared with the metabolically healthy group. The interaction between obesity status and metabolic health status on the risk of cancer mortality was not statistically significant (p=0.31). We found that the risk of cancer mortality decreased according to the obesity status and increased according to the metabolic health status. Given the rise in the rate of metabolic dysfunction, the mortality from cancer is also likely to rise. Treatment strategies targeting metabolic dysfunction may lead to reductions in the risk of death from cancer.
Highlights
Increasing rates of obesity and metabolic disturbance are becoming major public health problems in Korea (Wang et al, 2008; Finkelstein et al, 2012; Kang et al, 2014; Lee et al, 2014)
We investigated the risk of cancer mortality according to obesity status and metabolic health status using sampled cohort data from the National Health Insurance system
We found that the risk of cancer mortality decreased according to the obesity status and increased according to the metabolic health status
Summary
Increasing rates of obesity and metabolic disturbance are becoming major public health problems in Korea (Wang et al, 2008; Finkelstein et al, 2012; Kang et al, 2014; Lee et al, 2014). The risk of death from cancer increases with body mass index (BMI) (Jee et al, 2006; Lee et al, 2013). Moore et al (2014) reported that obesity and metabolic dysfunction act synergistically to increase the incidence risk of cancer (Moore et al, 2014). We investigated the risk of cancer mortality according to obesity status and metabolic health status using sampled cohort data from the National Health Insurance system. Materials and Methods: Data on body mass index and fasting blood glucose in the sampled cohort database (n=363,881) were used to estimate risk of cancer mortality. Conclusions: We found that the risk of cancer mortality decreased according to the obesity status and increased according to the metabolic health status. Treatment strategies targeting metabolic dysfunction may lead to reductions in the risk of death from cancer
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