Abstract
Among 6297 individuals reported to a kidney-transplant registry, the risk of developing lymphoma was about 35 times higher than normal and was derived almost entirely from a risk of reticulum-cell sarcoma, which was 350 times greater than expected. The excess lymphoma risk appeared within a year of transplantation, and remained at the same high level for the five or more years of follow-up. Skin and lip cancers occurred up to 4 times more often than expected. Other cancers were 2·5 times more common, in men only, due largely to soft-tissue sarcoma and hepatobiliary carcinoma. This excess risk of other cancers appeared later than that for the lymphomas and became more pronounced as the interval since transplantation increased.
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