Abstract
Serious neurological disorders reported following whole-cell (WC) in comparison to acellular (AC) pertussis vaccines (PV) were evaluated by the Genetic Centers of America, Silver Spring, MD.
Highlights
Serious neurological disorders reported following whole-cell (WC) in comparison to acellular (AC) pertussis vaccines (PV) were evaluated by the Genetic Centers of America, Silver Spring, MD
The Vaccine Adverse Events Reporting System (VAERS) was analyzed for ER visits, hospitalizations, disabilities, deaths, seizures, infantile spasms, encephalitis/encephalopathy, autism, SIDS, and speech disorders reported within 3 days following PV immunization in the US from 1997-1999
The incidence per million of reactions with WCPV/ACPV was for ER visits (72/32), diabilities (1.4/0.38), deaths (2.7/1.5), seizures (13.4/3.6), infantile spasms (0.39/0.11), encephalopathy (0.78/0.095), autism (0.49/0.11), SIDS (1.5/0.87), speech disorders (0.78/0.23), and cerebellar ataxia (0.29/0.27)
Summary
Serious neurological disorders reported following whole-cell (WC) in comparison to acellular (AC) pertussis vaccines (PV) were evaluated by the Genetic Centers of America, Silver Spring, MD. Longitudinal studies of MRS metabolites in Rasmussen encephalitis reveal a fluctuating metabolite profile related to seizure activity, indicating the limitations of MRS at a single point in the course of the disease. The Vaccine Adverse Events Reporting System (VAERS) was analyzed for ER visits, hospitalizations, disabilities, deaths, seizures, infantile spasms, encephalitis/encephalopathy, autism, SIDS, and speech disorders reported within 3 days following PV immunization in the US from 1997-1999.
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