Abstract
ObjectiveTo estimate the relative risk of autoimmune rheumatic diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), systemic sclerosis (SSc), Sjogren’s syndrome (SS), dermatomyositis (DM) and polymyositis (PM), among patients with palindromic rheumatism (PR) compared with non-PR individuals.MethodsThe study utilized 2003–2013 claims data from the Taiwanese National Health Insurance Research Database. We identified 4,421 cases of PR from 2007 to 2012 and randomly chose 44,210 non-PR individuals who matched (1:10) for age, sex and the year of index date without prior history of RA, SLE, SSc, SS, DM, or PM. After adjusting for age, sex, and the Charlson comorbidity index, we calculated the hazard ratios (HRs) with 95% confidence intervals (CIs) using the Cox proportional hazard model to quantify the risk of RA, SLE, SS, DM and PM in PR patients compared with that in matched non-PR individuals.ResultsAmong the 4,421 patients with PR, 569 (12.87%) developed RA, 269 (6.08%) developed SS, 113 (2.56%) developed SLE, 5 (0.11%) developed SSc, 8 (0.18%) developed PM, and 1 (0.02%) developed DM. After adjusting for potential confounders, the patients with PR had an increased risk of RA (HR, 118.76; 95% CI, 89.81–157.04), SS (HR, 59.57; 95% CI, 43.87–80.88), SLE (HR, 51.56; 95% CI, 32.96–80.66) PM (HR, 57.38; 95% CI, 6.90–476.83), and SSc (HR, 13.42; 95% CI, 3.79–47.55) but not of DM (HR, 3.44; 95% CI, 0.34–34.59).ConclusionPatients with PR had an increased risk of developing RA, SS, SLE, PM, and SSc.
Highlights
Palindromic rheumatism (PR) is a clinical disorder initially described in 1941 by Hernch and Rosenberg [1]
After adjusting for potential confounders, the patients with PR had an increased risk of rheumatoid arthritis (RA) (HR, 118.76; 95% confidence interval (CI), 89.81–157.04), s syndrome (SS) (HR, 59.57; 95% CI, 43.87–80.88), systemic lupus erythematosus (SLE) (HR, 51.56; 95% CI, 32.96–80.66) PM
The diagnostic criteria for PR were proposed by Guerne and Weismann in 1992 [4], consisting of the above characteristics with at least a six-month history and evidence of an attack observed by a physician
Summary
Palindromic rheumatism (PR) is a clinical disorder initially described in 1941 by Hernch and Rosenberg [1]. It is characterized by the episodic acute onset of para-arthritis or arthritis, involving one or several joints with variable and irregular symptom-free intervals [1, 2]. Each attack of PR usually lasts from a few hours to days, but rarely over one week [2]. An attack of PR is usually afebrile and subsides spontaneously. The diagnostic criteria for PR were proposed by Guerne and Weismann in 1992 [4], consisting of the above characteristics with at least a six-month history and evidence of an attack observed by a physician
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