Abstract
BackgroundSjögren’s syndrome (SS) has been associated with bronchial hyperresponsiveness and asthma; however, no population-based cohort study has been performed. We evaluated the risk of asthma in patients with primary SS in a nationwide population.MethodsWe conducted a retrospective cohort study using data from the National Health Insurance Research Database in Taiwan. The primary SS group included 4725 adult patients diagnosed between 2000 and 2006. Each patient was frequency-matched with four people without SS by sex, age and year of diagnosis. The occurrence and hazard ratio (HR) of asthma was monitored by the end of 2011.ResultsThe overall incidence density of asthma was 1.62-fold higher in the primary SS group than in the non-SS group (9.86 vs. 6.10 per 1000 person-years), with a multivariable Cox proportional hazards model measured adjusted HR of 1.38 [95% confidence interval (CI) = 1.21–1.58]. Stratified analyses by sex, age group, and presence of comorbidity revealed that asthma incidences were all higher in the primary SS group than in the non-SS group, and the relative HRs of asthma associated with primary SS were significant in all subgroups.ConclusionPatients with primary SS are associated with an increased risk of developing asthma. We should pay more attention to this group of individuals and provide them with appropriate support.
Highlights
Sjögren’s syndrome (SS) has been associated with bronchial hyperresponsiveness and asthma; no population-based cohort study has been performed
SS can present as an independent disorder itself or as a result of other autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), systemic sclerosis, or primary biliary cirrhosis [1, 2]
Prevalence rates of allergic rhinitis, chronic sinusitis, atopic dermatitis, chronic obstructive pulmonary disease (COPD), and gastroesophageal reflux disease (GERD) were all greater in patients with SS than individuals without SS (p < 0.001 for all)
Summary
Sjögren’s syndrome (SS) has been associated with bronchial hyperresponsiveness and asthma; no population-based cohort study has been performed. Sjögren’s syndrome (SS) is an autoimmune disease characterized by hypofunction of the lacrimal and salivary glands; the effects of SS are not limited to the eyes and mouth. 90% of primary SS cases are Asthma is a common respiratory disorder characterized by symptoms of wheezing, shortness of breath, chest tightness and cough. The occurrence, intensity, and frequency of these symptoms vary over time, and are associated with variable expiratory airflow, airway. Pollutants and irritants exposure, upper airway diseases, respiratory infections, female sex hormones, medications, obesity, and stressful life events have been associated with the adultonset asthma [9]
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