Risk of Antimicrobial Misuse

Salah Mesalhy Aly

doi:10.12816/0006014

Abstract

The limitation of legislations and shortage in implementation of regulatory measures regarding the uses of antimicrobials especially in developing countries, pay the attention of Scientists and UN organizations (FAO, OIE and WHO) to address the issues related to antimicrobial use/misuse, the emergence of resistant pathogens and the potential public health impact. As a scientists and being previously Expert Consultant for FAO, OIE and WHO of the UN, (1) we have concluded the following in this regard.

Highlights

The limitation of legislations and shortage in implementation of regulatory measures regarding the uses of antimicrobials especially in developing countries, pay the attention of Scientists and UN organizations (FAO, OIE and WHO) to address the issues related to antimicrobial use/misuse, the emergence of resistant pathogens and the potential public health impact
(2) Antimicrobial agent use in humans disturbs the microbiota of the intestinal tract, placing such individuals at increased risk of certain infections
(2) Resistant bacteria & Resistance genes: Development and spread of antimicrobial resistance as a consequence of exposure to antimicrobial agents is widely documented in human medicine.Transfer of R Plasmid and emergence of new drug resistance gene cassettes have been reported in human

Summary

Introduction

(2) Antimicrobial agent use in humans disturbs the microbiota of the intestinal tract, placing such individuals at increased risk of certain infections. Individuals taking an antimicrobial agent, for any reason, are at increased risk of becoming infected with pathogens resistant to the antimicrobial agent. (2) Resistant bacteria & Resistance genes: Development and spread of antimicrobial resistance as a consequence of exposure to antimicrobial agents is widely documented in human medicine.Transfer of R Plasmid and emergence of new drug resistance gene cassettes have been reported in human. It is generally acknowledged that, any use of antimicrobial agents can lead to the emergence of antimicrobial resistant microorganisms and further promote the dissemination of resistant bacteria and resistance genes.

Results

Conclusion