Abstract
Scientific evidence indicates the stabilization of indicators of morbidity and mortality from breast cancer in women in Ukraine and the existence of a number of models for predicting the breast cancer risk with the consideration of life style factors, detectable mutations of BRCA1 and BRCA2 genes, family history, as well as predicative and prognostic factors (clinical, molecular-biological) to determine the possible ways of the tumor process and the survival of breast cancer patients.
Highlights
Scientific evidence indicates the stabilization of indicators of morbidity and mortality
Некоторые модели способны прогнозировать как риски мутации гена, так и риски развития Рак молочной железы (РМЖ), однако точность этих моделей лимитирована
Summary
Scientific evidence indicates the stabilization of indicators of morbidity and mortality from breast cancer in women in Ukraine and the existence of a number of models for predicting the breast cancer risk with the consideration of life style factors, detectable mutations of BRCA1 and BRCA2 genes, family history, as well as predicative and prognostic factors (clinical, molecular-biological) to determine the possible ways of the tumor process and the survival of breast cancer patients. Риск заболеть РМЖ возрастает в течение жизни, однако более важным, чем возраст, фактором риска возникновения РМЖ является, вероятно, наличие отягощенной семейной истории. Разработаны модели прогнозирования вероятности мутации генов BRCA1 и BRCA2 для определения наследственной склонности к РМЖ [4].
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