Risk Group and Death From Prostate Cancer Among Men Undergoing Brachytherapy

Abstract

patients received a course of hormone deprivation for 6 months at least. One biochemical relapse was observed in this cohort of patients. Five patients died during the follow-up period without cancer relapse or toxicity. Acute genitourinary toxicity was observed in 81% of patients with maximal score of 2 in 40.9% of patients. Charlson score greater than 4 did not predict an increase in toxicity. Rectal acute toxicity grade 2 with mucosal discharge was present in 17.6% of patients. Presence of any acute rectal toxicity risk was increased by 2.3 fold in the shorter OTT (cut-point 47 days). Late rectal toxicity Grade 3 was seen in 1 patient, and 5 more patients showed a grade 2 score. Chronic urinary toxicity grades 1-2 were observed in 27.5% of patients, but only 2 patients had grade 2 urinary toxicity. Conclusion: IMAT with SIB to the prostate was well tolerated, with acceptable rates of acute and early late toxicity. Shorter OTT seems to increase the risk of acute rectal toxicity. Charlson score should not be considered as a predictor factor for toxicity. Additional follow-up is necessary to fully define the long-term toxicity. Author Disclosure: F. Ferrer: None. G. Mendez: None. C. Chiruzzi: None. H. Letelier: None. A. Boladeras: None. R. De Blas: None. R. Pineiro: None. M. Galdeano: None. D. Najjari: None. E. Zardoya: None. R. Chavez: None. M. Ventura: None. E. Martinez: None. C. Gutierrez: None. C. Picon: None. J. Pera: None. F. Guedea: None.