Risk factors of venous thromboembolism following lung cancer resection

Abstract

Objective To identify risk factors for postdischarge venous thromboembolism(VTE)following lung resection. Methods Patients undergoing anatomic resection for lung cancer were identified in our institution from 2005-2015. Patient demographic and clinical characteristics were evaluated for any association with post-discharge VTE. Predictors of post-discharge VTE were identified using multivariable analysis. Results VTE occurred in 1.6%(117) of the 7 154 patients identified. 43.6%(51) VTE events occurred following hospital discharge. Undergoing pneumonectomy was associated with a three-fold increased risk for post-discharge VTE compared with lobectomy(2.03% vs. 0.64%, P 75%) was also associated with increased risk for post-discharge VTE compared to shorter operative time. Multivariable analysis identified older age, obesity, pneumonectomy, and prolonged operative time as independent predictors for post-discharge VTE. Conclusion The risk for VTE extends after hospital discharge, few patients are managed with post-discharge prophylaxis. Post-discharge prophylaxis should be considered for those at high risk for VTE, particularly for older patients, those who are obese, and following extended or lengthy resections. Key words: Lung cancer surgery Venous thromboembolism Risk factors Prophylaxis