Risk Factors of Thrombosis of Pancreatic Graft: A Review

Farhan Asghar,Jun Hu

doi:10.4172/2161-0991.1000166

Abstract

One of the most common diseases that can affect human beings is Diabetes Mellitus. To that, Pancreas transplantation is the best known treatment so far but it also has some limitations. One of the most common reasons for failure is Thrombosis of pancreatic graft after transplantation. This review paper offers a brief history of transplantation and summary of those factors which can cause thrombosis of a pancreatic graft. There are two major groups for these factors; a) pre transplantation and b) post transplantation risk factors. The existing literature on thrombosis of pancreatic graft highlights those critical factors which could be one of the causes for thrombosis in a pancreatic graft. Pre transplantation risk factors include age of donor and recipient, gender of recipient, medical history of donor and recipient, ABO identity, duration of cold ischemia, administration of steroids and liquid of conservation. On the other hand, post-operative factors for thrombosis of pancreatic graft include venous anastomosis, microcirculation of graft, post-operative Von willebrand factor, post-operative hyperinsulinemia and type of pancreas transplantation. This review offers guidelines for pancreas transplantation in the light of these pre transplantation and post transplantation risk factors, so that surgeons can reduce the risk of thrombosis in a pancreatic graft.

Highlights

Diabetes Mellitus (DM) is the most common but critical disease which has affected the human beings significantly across the globe
Some complications which surgeon should enlist before the operation are listed in a major group as pre-transplant risk factor for venous thrombosis of the pancreatic graft second, those which are the causes of thrombosis after surgical process and we can enlist them as posttransplant risk factors
The changes of microcirculation in grafted pancreas play an important role in the occurrence of venous thrombosis and are represented by the following sequence: reperfusion - cellular death - edema - increase in local resistance to blood flow [12]

Summary

Introduction

Diabetes Mellitus (DM) is the most common but critical disease which has affected the human beings significantly across the globe. Et al [4] in December 1966, for the first time, performed pancreas transplantation with a renal graft to treat a type-I diabetes patient with uremia at the Hospital of the University of Minnesota, United States. Pancreatic transplantation is the best treatment for type 1 diabetes to establish a normoglycemia as effectively as a functional pancreas.

Results

Conclusion