RISK FACTORS OF PRE-CANCER CERVICAL DISEASES IN WOMEN OF REPRODUCTIVE AGE

Abstract

Relevance. Today, the nature of the impact of the inflammatory process caused by Trichomonas infection on the persistence of HPV and immune response, as a consequence of the progression of intraepithelial lesions of the cervix, is not fully understood.
 Objectives: based on a retrospective clinical and statistical analysis to determine the risk factors for cervical dysplasia in women of reproductive age.
 Materials and methods. A clinical and statistical analysis for 392 medical records of patients of reproductive age with verified HPV and Trichomonas Vaginalis, who received pathogenetic therapy at the clinical bases of the Bogomolets National Medical University Obstetrics and Gynecology № 3 Department and LLC "Clinic Profimed" for 2015-2019. As a result of a retrospective study of patients systematized by age, complaints, the presence of genital and extragenital pathology, reproductive history and the state of reproductive function, social status.
 Results. According to the analysis of anamnesis indicators, the main risk factors for precancerous cervical conditions were: early onset of sexual life, menstrual disorders (29.1%), high incidence of childhood infectious diseases (63.5%), somatic pathology (71.2 %), irregular use of barrier contraception (19.9%), genital diseased caused by sexually transmitted infections (STD), including HPV and Trichomonas Vaginalis, frequent abortions (41.6%) and childbirth with cervical trauma, low level of medical and sexual cultures and smoking (65.3%). The systemic negative impact of numerous risk factors on the body contributed to cervical intraepithelial neoplasia (CIN) development in women of reproductive age.
 Conclusion. The retrospective study proves the need for stratification of patients with for CIN risk, requires management of cervical pathology in women with HPV and detected Trichomonas Vaginalis, which will increase the effectiveness of diagnosis, treatment and recurrence prevention.